The Pip-Boy 3000 Mark IV is the fourth iteration of the Pip-Boy 3000 line and includes a number of design enhancements. The control dials were moved from the left side of the device to the right to improve accessibility, and the biometric lock and glove were replaced by a simple latch, allowing for quick and easy removal. The Mark IV also utilized a revamped display interface with animated images and was capable of playing the latest video games, such as Atomic Command and Red Menace.

The Pip-Boy 3000 Mark IV was distributed to vaults near Boston, including Vault 75, Vault 81, Vault 95, Vault 111, and Vault 114. Vault-Tec staff did not grant Pip-Boys to the residents of Vault 111 due to their placement in cryogenic stasis; the Sole Survivor of the vault was able to claim a Pip-Boy from the corpse of a long-dead Vault-Tec scientist.

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